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pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers raise amount of toremifene metabolism, decreasing the continuous-condition focus in serum.pentobarbital will decrease the level or result of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 m